Gene Set: CYCLIN_D1_KE_.V1_DN

Standard name CYCLIN_D1_KE_.V1_DN
Systematic name M2647
Brief description Genes down-regulated in MCF-7 cells (breast cancer) over-expressing a mutant K112E form of CCND1 [GeneID=595] gene.
Full description or abstract Here we describe how patterns of gene expression in human tumors have been deconvoluted to reveal a mechanism of action for the cyclin D1 oncogene. Computational analysis of the expression patterns of thousands of genes across hundreds of tumor specimens suggested that a transcription factor, C/EBPbeta/Nf-Il6, participates in the consequences of cyclin D1 overexpression. Functional analyses confirmed the involvement of C/EBPbeta in the regulation of genes affected by cyclin D1 and established this protein as an indispensable effector of a potentially important facet of cyclin D1 biology. This work demonstrates that tumor gene expression databases can be used to study the function of a human oncogene in situ.
Collection C6: oncogenic signature gene sets
Source publication Pubmed 12914697   Authors: Lamb J,Ramaswamy S,Ford HL,Contreras B,Martinez RV,Kittrell FS,Zahnow CA,Patterson N,Golub TR,Ewen ME
Exact source cyclin D1 (K112E) vs control; bottom 200 genes (diff-means)
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(show 263 gene sets from the same authors)
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Organism Homo sapiens
Contributed by Pablo Tamayo (Broad Institute)
Source platform HUMAN_GENE_SYMBOL
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