Gene Set: DCA_UP.V1_DN

Standard name DCA_UP.V1_DN
Systematic name M2760
Brief description Genes down-regulated in A549 lung carcinoma and M059K glioblastoma cells treated with dichloroacetate [PubChem=6597].
Full description or abstract Analysis of A549 lung carcinoma and M059K glioblastoma cells treated with dichloroacetate (DCA), an inhibitor of the mitochondrial pyruvate dehydrogenase kinase. DCA shifts metabolism from glycolysis to glucose oxidation and decreases mitochondrial membrane potential in cancer cells.
Collection C6: oncogenic signature gene sets
Source publication Pubmed 17222789   Authors: Bonnet S,Archer SL,Allalunis-Turner J,Haromy A,Beaulieu C,Thompson R,Lee CT,Lopaschuk GD,Puttagunta L,Bonnet S,Harry G,Hashimoto K,Porter CJ,Andrade MA,Thebaud B,Michelakis ED
Exact source DCA vs Controls; bottom 200 genes (diff. of means)
Related gene sets (show 1 additional gene sets from the source publication)

(show 13 gene sets from the same authors)
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Organism Homo sapiens
Contributed by Pablo Tamayo (Broad Institute)
Source platform HUMAN_GENE_SYMBOL
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Compendia expression profiles GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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