Human Gene Set: DISTECHE_ESCAPED_FROM_X_INACTIVATION
Standard name
DISTECHE_ESCAPED_FROM_X_INACTIVATION
Systematic name
M16091
Brief description
Genes that escape X inactivation.
Full description or abstract
Although the process of X inactivation in mammalian cells silences the majority of genes on the inactivated X chromosome, some genes escape this chromosome-wide silencing. Genes that escape X inactivation present a unique opportunity to study the process of silencing and the mechanisms that protect some genes from being turned off. In this review, we will discuss evolutionary aspects of escape from X inactivation, in relation to the divergence of the sex chromosomes. Molecular characteristics, expression, and epigenetic modifications of genes that escape will be presented, including their developmental regulation and the implications of chromatin domains along the X chromosome in modeling the escape process.
Collection
C2: Curated CGP: Chemical and Genetic Perturbations
