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Human Gene Set: FOURATI_BLOOD_TWINRIX_AGE_65_83YO_POOR
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Standard name | FOURATI_BLOOD_TWINRIX_AGE_65_83YO_POOR_RESPONDERS_VS_RESPONDERS_0DY_NETWORK_INFERENCE_UP | ||||||||||||||||||||||||||||
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Systematic name | M41046 | ||||||||||||||||||||||||||||
Brief description | Genes up-regulated in blood poor responders vs responders in seniors (65-83) (poor responders) after exposure to Twinrix , time point 0D. Comment: Networks were inferred for the BioAge module 1 combined to the 15-gene signature and the BioAge module 16 combined to the 15-gene signature, respectively. | ||||||||||||||||||||||||||||
Full description or abstract | Aging is associated with hyporesponse to vaccination, whose mechanisms remain unclear. In this study hepatitis B virus (HBV)-naive older adults received three vaccines, including one against HBV. Here we show, using transcriptional and cytometric profiling of whole blood collected before vaccination, that heightened expression of genes that augment B-cell responses and higher memory B-cell frequencies correlate with stronger responses to HBV vaccine. In contrast, higher levels of inflammatory response transcripts and increased frequencies of pro-inflammatory innate cells correlate with weaker responses to this vaccine. Increased numbers of erythrocytes and the haem-induced response also correlate with poor response to the HBV vaccine. A transcriptomics-based pre-vaccination predictor of response to HBV vaccine is built and validated in distinct sets of older adults. This moderately accurate (area under the curve ~65%) but robust signature is supported by flow cytometry and cytokine profiling. This study is the first that identifies baseline predictors and mechanisms of response to the HBV vaccine. | ||||||||||||||||||||||||||||
Collection | C7: Immunologic Signature VAX: HIPC Vaccine Response |
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Source publication | Pubmed 26742691 Authors: Fourati S,Cristescu R,Loboda A,Talla A,Filali A,Railkar R,Schaeffer AK,Favre D,Gagnon D,Peretz Y,Wang IM,Beals CR,Casimiro DR,Carayannopoulos LN,Sékaly RP | ||||||||||||||||||||||||||||
Exact source | Discussion; Fig 4E | ||||||||||||||||||||||||||||
Related gene sets |
(show 4 additional gene sets from the source publication)
FOURATI_BLOOD_TWINRIX_AGE_25_83YO_RESPONDERS_VS_POOR_RESPONDERS_0DY_DN FOURATI_BLOOD_TWINRIX_AGE_25_83YO_RESPONDERS_VS_POOR_RESPONDERS_0DY_UP FOURATI_BLOOD_TWINRIX_AGE_65_81Y0_RESPONDERS_VS_POOR_RESPONDERS_TRAINING_SET_0DY_NETWORK_INFERENCE_UP FOURATI_BLOOD_TWINRIX_AGE_65_81YO_RESPONDERS_VS_POOR_RESPONDERS_TRAINING_SET_0DY_NETWORK_INFERENCE_DN (show 12 gene sets from the same authors) GAUCHER_PBMC_YF_VAX_STAMARIL_UNKNOWN_AGE_10DY_DN GAUCHER_PBMC_YF_VAX_STAMARIL_UNKNOWN_AGE_10DY_UP GAUCHER_PBMC_YF_VAX_STAMARIL_UNKNOWN_AGE_14DY_DN GAUCHER_PBMC_YF_VAX_STAMARIL_UNKNOWN_AGE_14DY_UP GAUCHER_PBMC_YF_VAX_STAMARIL_UNKNOWN_AGE_28DY_DN GAUCHER_PBMC_YF_VAX_STAMARIL_UNKNOWN_AGE_28DY_UP GAUCHER_PBMC_YF_VAX_STAMARIL_UNKNOWN_AGE_3DY_DN GAUCHER_PBMC_YF_VAX_STAMARIL_UNKNOWN_AGE_3DY_UP GAUCHER_PBMC_YF_VAX_STAMARIL_UNKNOWN_AGE_60DY_DN GAUCHER_PBMC_YF_VAX_STAMARIL_UNKNOWN_AGE_60DY_UP GAUCHER_PBMC_YF_VAX_STAMARIL_UNKNOWN_AGE_7DY_DN GAUCHER_PBMC_YF_VAX_STAMARIL_UNKNOWN_AGE_7DY_UP |
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External links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729923/figure/f4/ |
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Filtered by similarity ? | |||||||||||||||||||||||||||||
Source species | Homo sapiens | ||||||||||||||||||||||||||||
Contributed by | HIPC SIGNATURES (NIAID/HIPC SIGNATURES) | ||||||||||||||||||||||||||||
Source platform or identifier namespace |
HUMAN_GENE_SYMBOL | ||||||||||||||||||||||||||||
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(show 6 source identifiers mapped to 5 genes)
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Version history | 7.3: First Introduced. |
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