Human Gene Set: GOBP_REPLICATIVE_SENESCENCE

For the Mouse gene set with the same name, see GOBP_REPLICATIVE_SENESCENCE

Standard name GOBP_REPLICATIVE_SENESCENCE
Systematic name M14683
Brief description The process by which normal somatic cells reach an irreversible stage of cell cycle arrest following multiple rounds of replication; this end stage is associated with marked changes in gene expression and function. This is a natural barrier to unlimited proliferation of somatic cells, and is believed to be contolled by telomere shortening. [PMID:17014937, PMID:23061726]
Full description or abstract  
Collection C5: Ontology
      GO: Gene Ontology
            GO:BP: GO Biological Process
Source publication  
Exact source GO:0090399
Related gene sets  
External links http://amigo.geneontology.org/amigo/term/GO:0090399
Filtered by similarity ?
Source species Homo sapiens
Contributed by Gene Ontology (Gene Ontology Consortium)
Source platform or
identifier namespace		 Human_NCBI_Gene_ID
Dataset references  
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 17 genes
Gene families ? Categorize these 17 genes by gene family
Show members (show 17 source identifiers mapped to 17 genes)
Version history 2025.1.Hs: Updated to GO Release 2025-03-16.


Creative Commons Attribution 4.0 International License (CC-BY-4.0)

The contents of this gene set are protected by copyright (c) 2004-2026 Broad Institute, Inc., Massachusetts Institute of Technology, and Regents of the University of California, subject to the terms and conditions of the Creative Commons Attribution 4.0 International License.

See the full MSigDB license terms here.