Human Gene Set: GOCC_EUKARYOTIC_48S_PREINITIATION_COMPLEX
Standard name
GOCC_EUKARYOTIC_48S_PREINITIATION_COMPLEX
Systematic name
M46938
Brief description
The protein-ribosome-tRNA complex that has just recognized the start codon of a capped mRNA. It is composed of the small ribosomal subunit, eukaryote initiation factors (eIF) eIF3 complex, eIF1, eIF1A, eIF2-GDP, eIF4 complex and initiatior-methionine-tRNA. Recognition of the start codon triggers downstream steps in the pathway, including eIF1 dissociation; Pi release from eIF2; and conversion to the closed, scanning-arrested conformation of the PIC. [GOC:hjd, PMID:16510876, PMID:24319994, PMID:24499181, PMID:29735639]
Full description or abstract
Collection
C5: Ontology GO: Gene Ontology GO:CC: GO Cellular Component
