Human Gene Set: GSE30153_LUPUS_VS_HEALTHY_DONOR_BCELL_DN


Standard name GSE30153_LUPUS_VS_HEALTHY_DONOR_BCELL_DN
Systematic name M8424
Brief description Genes down-regulated in B lymphocytes: systemic lupus erythematosous (SLE) versus healthy.
Full description or abstract Systemic lupus erythematosous (SLE) is an autoimmune disease with an important clinical and biological heterogeneity. B lymphocytes appear central to the development of SLE which is characterized by the production of a large variety of autoantibodies and hypergammaglobulinemia. In mice, immature B cells from spontaneous lupus prone animals are able to produce autoantibodies when transferred into immunodeficient mice, strongly suggesting the existence of intrinsic B cell defects during lupus. In order to approach these defects in humans, we compared the peripheral B cell transcriptomes of quiescent lupus patients to normal B cell transcriptomes.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 21886837   Authors: Garaud JC,Schickel JN,Blaison G,Knapp AM,Dembele D,Ruer-Laventie J,Korganow AS,Martin T,Soulas-Sprauel P,Pasquali JL
Exact source GSE30153_3539_200_DN
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Source species Homo sapiens
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
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identifier namespace		 HUMAN_GENE_SYMBOL
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Version history 7.3: Moved to ImmuneSigDB sub-collection.


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