Gene Set: LEF1_UP.V1_DN

Standard name LEF1_UP.V1_DN
Systematic name M2903
Brief description Genes down-regulated in DLD1 cells (colon carcinoma) over-expressing LEF1 [GeneID=51176].
Full description or abstract We treated DLD1 cells with an adenoviral LEF-1 expression construct, which induced EMT within 48 hours. RNA was then extracted from these cells along with untreated DLD1 cells, then subjected to microarray analysis.
Collection C6: oncogenic signature gene sets
Source publication Authors: Medici D,Hay E,Olsen B
Exact source DLD1+LEF-1 vs DLD1; bottom 150 genes
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Organism Homo sapiens
Contributed by Pablo Tamayo (Broad Institute)
Source platform HUMAN_GENE_SYMBOL
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Compendia expression profiles GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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