Gene Set: NOTCH_DN.V1_UP

Standard name NOTCH_DN.V1_UP
Systematic name M2789
Brief description Genes up-regulated in MOLT4 cells (T-ALL) by DAPT [PubChem=16219261], an inhibitor of NOTCH signaling pathway.
Full description or abstract NOTCH signaling in T-ALL cell lines. Three independent cultures of the MOLT4 cell line before and 48 hours after addition of the gamma-secretase inhibitor DAPT (5 uM).
Collection C6: oncogenic signature gene sets
Source publication Pubmed 17560996   Authors: Dohda T,Maljukova A,Liu L,Heyman M,Grander D,Brodin D,Sangfelt O,Lendahl U
Exact source Controls vs DAPT; bottom 200 genes (diff. of means)
Related gene sets (show 1 additional gene sets from the source publication)
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Organism Homo sapiens
Contributed by Pablo Tamayo (Broad Institute)
Source platform HUMAN_GENE_SYMBOL
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Compendia expression profiles GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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