|
|
 |
Human Gene Set: PATEL_SKIN_OF_BODY_ZOSTAVAX_AGE_70_93YO
|
| Standard name | PATEL_SKIN_OF_BODY_ZOSTAVAX_AGE_70_93YO_VZV_CHALLENGED_POST_VACCINATION_VS_UNCHALLENGED_72HR_TOP_30_DEG_UP |
|---|---|
| Systematic name | M40975 |
| Brief description | Genes up-regulated in skin of body VZV challenged post-vaccination vs unchallenged in adults (70-93) (VZV challenge) after exposure to Zostavax , time point 72H. Comment: Table showing the top 30 genes upregulated at 72 hours after varicella zoster virus (VZV) challenge before and after vaccination. |
| Full description or abstract | Background: The live attenuated vaccine Zostavax was developed to prevent varicella zoster virus (VZV) reactivation that causes herpes zoster (shingles) in older humans. However, the impact of vaccination on the cutaneous response to VZV is not known. Methods: We investigated the response to intradermal VZV antigen challenge before and after Zostavax vaccination in participants > 70 years of age by immunohistological and transcriptomic analyses of skin biopsy specimens collected from the challenge site. Results: Vaccination increased the proportion of VZV-specific CD4+ T cells in the blood and promoted the accumulation of both CD4+ and CD8+ T cells in the skin after VZV antigen challenge. However, Zostavax did not alter the proportion of resident memory T cells (CD4+ and CD8+) or CD4+Foxp3+ regulatory T cells in unchallenged skin. After vaccination, there was increased cutaneous T-cell proliferation at the challenge site and also increased recruitment of T cells from the blood, as indicated by an elevated T-cell migratory gene signature. CD8+ T-cell-associated functional genes were also highly induced in the skin after vaccination. Conclusion: Zostavax vaccination does not alter the abundance of cutaneous resident memory T cells but instead increases the recruitment of VZV-specific T cells from the blood and enhances T-cell activation, particularly cells of the CD8+ subset, in the skin after VZV antigen challenge. |
| Collection | C7: Immunologic Signature VAX: HIPC Vaccine Response |
| Source publication | Pubmed 30247603 Authors: Patel NP,Vukmanovic-Stejic M,Suarez-Farinas M,Chambers ES,Sandhu D,Fuentes-Duculan J,Mabbott NA,Rustin MHA,Krueger J,Akbar AN |
| Exact source | Fig 6A |
| Related gene sets |
(show 5 additional gene sets from the source publication)
(show 2 gene sets from the same authors) |
| External links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151076/figure/F6/ |
| Filtered by similarity ? | |
| Source species | Homo sapiens |
| Contributed by | HIPC SIGNATURES (NIAID/HIPC SIGNATURES) |
| Source platform or identifier namespace |
HUMAN_GENE_SYMBOL |
| Dataset references | |
| Download gene set | format: grp | gmt | xml | json | TSV metadata |
| Compute overlaps ? |
(show collections to investigate for overlap with this gene set)
|
| Compendia expression profiles ? |
NG-CHM interactive heatmaps (Please note that clustering takes a few seconds) Legacy heatmaps (PNG) |
| Advanced query | Further investigate these 30 genes |
| Gene families ? | Categorize these 30 genes by gene family |
| Show members |
(show 30 source identifiers mapped to 30 genes)
|
| Version history | 7.3: First Introduced. |
See MSigDB license terms here. Please note that certain gene sets have special access terms.
