Human Gene Set: RECHTIEN_PBMC_RVSV_ZEBOV_AGE_18_55YO_1DY_UP


Standard name RECHTIEN_PBMC_RVSV_ZEBOV_AGE_18_55YO_1DY_UP
Systematic name M40942
Brief description Genes up-regulated in peripheral blood mononuclear cell 1d vs 0d in adults (18-55) after exposure to rVSV-ZEBOV , time point 1D
Full description or abstract Predicting vaccine efficacy remains a challenge. We used a systems vaccinology approach to identify early innate immune correlates of antibody induction in humans receiving the Ebola vaccine rVSV-ZEBOV. Blood samples from days 0, 1, 3, 7, and 14 were analyzed for changes in cytokine levels, innate immune cell subsets, and gene expression. Integrative statistical analyses with cross-validation identified a signature of 5 early innate markers correlating with antibody titers on day 28 and beyond. Among those, IP-10 on day 3 and MFI of CXCR6 on NK cells on day 1 were independent correlates. Consistently, we found an early gene expression signature linked to IP-10. This comprehensive characterization of early innate immune responses to the rVSV-ZEBOV vaccine in humans revealed immune signatures linked to IP-10. These results suggest correlates of vaccine-induced antibody induction and provide a rationale to explore strategies for augmenting the effectiveness of vaccines through manipulation of IP-10.
Collection C7: Immunologic Signature
      VAX: HIPC Vaccine Response
Source publication Pubmed 28854372   Authors: Rechtien A,Richert L,Lorenzo H,Martrus G,Hejblum B,Dahlke C,Kasonta R,Zinser M,Stubbe H,Matschl U,Lohse A,Krähling V,Eickmann M,Becker S,VEBCON Consortium,Thiébaut R,Altfeld M,Addo MM
Exact source Table 2, NFKB1 and NFKB2 mentioned in text
Related gene sets (show 20 gene sets from the same authors)
External links https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583508/table/tbl2/
Filtered by similarity ?
Source species Homo sapiens
Contributed by HIPC SIGNATURES (NIAID/HIPC SIGNATURES)
Source platform or
identifier namespace
HUMAN_GENE_SYMBOL
Dataset references  
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 10 genes
Gene families ? Categorize these 10 genes by gene family
Show members (show 10 source identifiers mapped to 10 genes)
Version history 7.3: First Introduced.

See MSigDB license terms here. Please note that certain gene sets have special access terms.