Gene Set: SNF5_DN.V1_DN

Standard name SNF5_DN.V1_DN
Systematic name M2715
Brief description Genes down-regulated in MEF cells (embryonic fibroblasts) with knockout of SNF5 [GeneID=6598] gene.
Full description or abstract Snf5 (Ini1/Baf47/Smarcb1), a core member of the Swi/Snf chromatin remodeling complex, is a potent tumor suppressor whose mechanism of action is largely unknown. Biallelic loss of Snf5 leads to the onset of aggressive cancers in both humans and mice. We have developed an innovative and widely applicable analytical technique for cross-species validation of cancer models and show that the gene expression profiles of our Snf5 murine models closely resemble those of human Snf5-deficient rhabdoid tumors. We exploit this system to produce what we believe to be the first report documenting the effects on gene expression of inactivating a Swi/Snf subunit in normal mammalian cells and to identify the transcriptional pathways regulated by Snf5. We demonstrate that the tumor suppressor activity of Snf5 depends on its regulation of cell cycle progression; Snf5 inactivation leads to aberrant up-regulation of E2F targets and increased levels of p53 that are accompanied by apoptosis, polyploidy, and growth arrest. Further, conditional mouse models demonstrate that inactivation of p16Ink4a or Rb (retinoblastoma) does not accelerate tumor formation in Snf5 conditional mice, whereas mutation of p53 leads to a dramatic acceleration of tumor formation.
Collection C6: oncogenic signature gene sets
Source publication Pubmed 16301525   Authors: Isakoff MS,Sansam CG,Tamayo P,Subramanian A,Evans JA,Fillmore CM,Wang X,Biegel JA,Pomeroy SL,Mesirov JP,Roberts CW
Exact source SNF5- vs Controls; bottom 200 genes (diff. of means)
Related gene sets (show 1 additional gene sets from the source publication)

(show 214 gene sets from the same authors)
External links  
Filtered by similarity
Organism Mus musculus
Contributed by Pablo Tamayo (Broad Institute)
Source platform HUMAN_GENE_SYMBOL
Dataset references  
Download gene set format: grp | text | gmt | gmx | xml
Compute overlaps (show collections to investigate for overlap with this gene set)
Compendia expression profiles GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 157 genes
Gene families Categorize these 157 genes by gene family
Show members (show 200 members mapped to 157 genes)
Version history 7.1: Fixed RIKEN identifiers.

See MSigDB license terms here. Please note that certain gene sets have special access terms.