Gene Set: STK33_UP

Standard name STK33_UP
Systematic name M2858
Brief description Genes up-regulated in NOMO-1 and SKM-1 cells (AML) after knockdown of STK33 [GeneID=65975] by RNAi.
Full description or abstract NOMO-1 and SKM-1 acute myeloid leukemia (AML) cells were stably transduced with different pLKO.1puro lentiviral shRNA vectors targeting STK33 or a nontargeting control shRNA. VSV-G-pseudotyped lentiviral particles were produced by cotransfection of 293T cells with pLKO.1 constructs and the compatible packaging plasmids pMD.G and pCMVR8.91. Virus was harvested 48 and 72 hours after transfection, cells were incubated with lentiviral supernatants for 30 hours, and infected cells were selected with 2ug/ml puromycin. RNA was isolated after 2 days of puromycin selection and isolation of viable cells by density gradient centrifugation, and gene expression was profiled using GeneChip Human Genome U133 Plus 2.0 microarrays (Affymetrix).
Collection C6: oncogenic signature gene sets
Source publication Pubmed 19490892   Authors: Scholl C,Froehling S,Dunn IF,Schinzel AC,Barbie DA,Kim SY,Silver SJ,Tamayo P,Wadlow RC,Ramaswamy S,Doehner K,Bullinger L,Sandy P,Boehm JS,Root DE,Jacks T,Hahn WC,Gilliland DG
Exact source control vs KD STK33 in nomo & skm cells; top 300 genes (diff. of means)
Related gene sets (show 5 additional gene sets from the source publication)

(show 380 gene sets from the same authors)
External links  
Filtered by similarity
Organism Homo sapiens
Contributed by Pablo Tamayo (Broad Institute)
Source platform HUMAN_GENE_SYMBOL
Dataset references (show 1 datasets)
Download gene set format: grp | text | gmt | gmx | xml
Compute overlaps (show collections to investigate for overlap with this gene set)
Compendia expression profiles GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 285 genes
Gene families Categorize these 285 genes by gene family
Show members (show 300 members mapped to 285 genes)
Version history  

See MSigDB license terms here. Please note that certain gene sets have special access terms.