Systematic name M4357
Brief description Genes down-regulated in pro-B lymphocytes after knockout of CREBBP [GeneID=1387].
Full description or abstract CREB-binding protein (CBP) and its para-log p300 are transcriptional coactivators that physically or functionally interact with over 320 mammalian and viral proteins, including 36 that are essential for B cells in mice. CBP and p300 are generally considered limiting for transcription, yet their roles in adult cell lineages are largely unknown since homozygous null mutations in either gene or compound heterozygosity cause early embryonic lethality in mice. We tested the hypotheses that CBP and p300 are limiting and that each has unique properties in B cells, by using mice with Cre/LoxP conditional knockout alleles for CBP (CBP(flox)) and p300 (p300(flox)), which carry CD19(Cre) that initiates floxed gene recombination at the pro-B-cell stage. CD19(Cre)-mediated loss of CBP or p300 led to surprisingly modest deficits in B-cell numbers, whereas inactivation of both genes was not tolerated by peripheral B cells. There was a moderate decrease in B-cell receptor (BCR)-responsive gene expression in CBP or p300 homozygous null B cells, suggesting that CBP and p300 are essential for this signaling pathway that is crucial for B-cell homeostasis. These results indicate that individually CBP and p300 are partially limiting beyond the pro-B-cell stage and that other coactivators in B cells cannot replace their combined loss.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 16424387   Authors: Xu W,Fukuyama T,Ney PA,Wang D,Rehg J,Boyd K,van Deursen JM,Brindle PK
Exact source Table 2
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(show 14 gene sets from the same authors)
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Organism Mus musculus
Contributed by Kevin Vogelsang (MSigDB Team)
Source platform AFFY_MG_U74
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Version history 3.0: Renamed from XU_CBP_DN

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