Human Gene Set: ZHU_CMV_8_HR_UP


Standard name ZHU_CMV_8_HR_UP
Systematic name M4710
Brief description Up-regulated at 8 h following infection of primary human foreskin fibroblasts with CMV
Full description or abstract Mechanistic insights to viral replication and pathogenesis generally have come from the analysis of viral gene products, either by studying their biochemical activities and interactions individually or by creating mutant viruses and analyzing their phenotype. Now it is possible to identify and catalog the host cell genes whose mRNA levels change in response to a pathogen. We have used DNA array technology to monitor the level of approximately 6,600 human mRNAs in uninfected as compared with human cytomegalovirus-infected cells. The level of 258 mRNAs changed by a factor of 4 or more before the onset of viral DNA replication. Several of these mRNAs encode gene products that might play key roles in virus-induced pathogenesis, identifying them as intriguing targets for further study.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 9826724   Authors: Zhu H,Cong JP,Mamtora G,Gingeras T,Shenk T
Exact source Table 1: 8 h U
Related gene sets (show 5 additional gene sets from the source publication)

(show 29 gene sets from the same authors)
External links
Filtered by similarity ?
Source species Homo sapiens
Contributed by John Newman (University of Washington)
Source platform or
identifier namespace
HUMAN_SEQ_ACCESSION
Dataset references  
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 41 genes
Gene families ? Categorize these 41 genes by gene family
Show members (show 50 source identifiers mapped to 41 genes)
Version history 3.0: Renamed from CMV_8HRS_UP

See MSigDB license terms here. Please note that certain gene sets have special access terms.