Mouse Gene Set: GOCC_HETEROMERIC_SMAD_PROTEIN_COMPLEX


Standard name GOCC_HETEROMERIC_SMAD_PROTEIN_COMPLEX
Systematic name MM12465
Brief description A protein complex composed of SMAD family proteins, a transcription factor complex which binds to the promoters of target genes and recruits co-activators and histone acetyltransferases, facilitating transcription. Phosphorylation of the non-SMAD4 subunit(s) enables binding of SMAD4 to form heteromeric complexes that enter the nucleus to initiate gene transcription. DNA-binding specificity is conferred by other transcription factors binding to SMAD complexes. Interactions with coactivators or corepressors modulate their transcriptional activity. Can be heterotrimeric or heterodimeric. [GOC:bhm, GOC:mah, PMID:11779505, PMID:15350224, PMID:16322555, PMID:9389648, PMID:9670020]
Full description or abstract  
Collection M5: Ontology
      GO: Gene Ontology
            GO:CC: GO Cellular Component
Source publication  
Exact source GO:0071144
Related gene sets  
External links http://amigo.geneontology.org/amigo/term/GO:0071144
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Source species Mus musculus
Contributed by Gene Ontology (Gene Ontology Consortium)
Source platform or
identifier namespace
Mouse_NCBI_Gene_ID
Dataset references  
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