Mouse Gene Set: GOLDRATH_HOMEOSTATIC_PROLIFERATION

For the Human gene set with the same name, see GOLDRATH_HOMEOSTATIC_PROLIFERATION

Standard name GOLDRATH_HOMEOSTATIC_PROLIFERATION
Systematic name MM613
Brief description Up-regulated in CD8+ [GeneID=925] T lymphocytes undergoing homeostatic proliferation (HP) versus the naive cells; these genes are not up-regulated versus effector or memory cell population.
Full description or abstract Naive T cells proliferate independently of cognate antigen when introduced into lymphopenic hosts. Lymphopenia-induced proliferation depends on low-affinity MHC/self-peptide complexes and on IL-7. To elucidate the intracellular signals mediating this proliferation, we analyzed changes in gene expression in naive CD8+ T cells at different times after their transfer into a lymphopenic environment. The genes induced in response to lymphopenia were largely an attenuated subset of those turned up by full antigenic stimulation, including genes related to cell cycling, whereas excluding genes specifically associated with effector activity. After the initial phase of proliferation in an empty compartment, the naive T cells adopted a stable pattern of gene expression similar to that of antigen-experienced memory cells. Thus, T cells proliferating in lymphopenic hosts do not exhibit a unique gene-expression profile, instead relying on traditional signals for this antigen-independent proliferation; this process ultimately results in differentiation to authentic memory cells.
Collection M2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 15548615   Authors: Goldrath AW,Luckey CJ,Park R,Benoist C,Mathis D
Exact source Table 5S
Related gene sets (show 2 additional gene sets from the source publication)
External links
Filtered by similarity ?
Source species Mus musculus
Contributed by Kate Stafford (MSigDB Team)
Source platform or
identifier namespace		 AFFY_MG_U74
Dataset references (show 1 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
Mouse Transcriptomic BodyMap compendium

Legacy heatmaps (PNG)
Mouse Transcriptomic BodyMap compendium
Advanced query Further investigate these 155 genes
Show members (show 199 source identifiers mapped to 155 genes)
Version history 2022.1.Mm: First Introduced.

See MSigDB license terms here. Please note that certain gene sets have special access terms.