Mouse Gene Set: TSENG_ADIPOGENIC_POTENTIAL_UP

For the Human gene set with the same name, see TSENG_ADIPOGENIC_POTENTIAL_UP

Standard name TSENG_ADIPOGENIC_POTENTIAL_UP
Systematic name MM704
Brief description Genes showing increasing expression in brown preadipocytes with decreasing ability of the cells to differentiate.
Full description or abstract The insulin/IGF-1 (insulin-like growth factor 1) signalling pathway promotes adipocyte differentiation via complex signalling networks. Here, using microarray analysis of brown preadipocytes that are derived from wild-type and insulin receptor substrate (Irs) knockout animals that exhibit progressively impaired differentiation, we define 374 genes/expressed-sequence tags whose expression in preadipocytes correlates with the ultimate ability of the cells to differentiate. Many of these genes, including preadipocyte factor-1 (Pref-1) and multiple members of the Wnt signalling pathway, are related to early adipogenic events. Necdin is also markedly increased in Irs knockout cells that cannot differentiate, and knockdown of necdin restores brown adipogenesis with downregulation of Pref-1 and Wnt10a expression. Insulin receptor substrate proteins regulate a necdin-E2F4 interaction that represses peroxisome-proliferator-activated receptor gamma (PPARgamma) transcription via a cyclic AMP response element binding protein (CREB)-dependent pathway. Together these define a key signalling network that is involved in brown preadipocyte determination.
Collection M2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 15895078   Authors: Tseng YH,Butte AJ,Kokkotou E,Yechoor VK,Taniguchi CM,Kriauciunas KM,Cypess AM,Niinobe M,Yoshikawa K,Patti ME,Kahn CR
Exact source Fig. 2S: Up progression
Related gene sets (show 3 additional gene sets from the source publication)

(show 1 gene sets from the same authors)
External links
Filtered by similarity ?
Source species Mus musculus
Contributed by John Newman (University of Washington)
Source platform or
identifier namespace		 AFFY_MG_U74
Dataset references (show 1 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
Mouse Transcriptomic BodyMap compendium

Legacy heatmaps (PNG)
Mouse Transcriptomic BodyMap compendium
Advanced query Further investigate these 31 genes
Show members (show 33 source identifiers mapped to 31 genes)
Version history 2022.1.Mm: First Introduced.

See MSigDB license terms here. Please note that certain gene sets have special access terms.