Human Gene Set: BASSO_HAIRY_CELL_LEUKEMIA_UP


Standard name BASSO_HAIRY_CELL_LEUKEMIA_UP
Systematic name M13859
Brief description Genes up-regulated in hairy cell leukemia (HCL) compared with normal and other neoplastic B cell populations.
Full description or abstract Hairy cell leukemia (HCL) is a chronic B cell malignancy characterized by the diffuse infiltration of bone marrow and spleen by cells displaying a typical hairy morphology. However, the nature of the HCL phenotype and its relationship to normal B cells and to other lymphoma subtypes remains unclear. Using gene expression profiling, we show here that HCL displays a homogeneous pattern of gene expression, which is clearly distinct from that of other B cell non-Hodgkin lymphomas. Comparison with the gene expression profiles of purified normal B cell subpopulations, including germinal center (GC), pre-GC (naive), and post-GC (memory) B cells, shows that HCL cells are more related to memory cells, suggesting a derivation from this B cell population. Notably, when compared with memory cells, HCL cells displayed a remarkable conservation in proliferation, apoptosis, and DNA metabolism programs, whereas they appeared significantly altered in the expression of genes controlling cell adhesion and response to chemokines. Finally, these analyses have identified several genes that are specifically expressed in HCL and whose expression was confirmed at the protein level by immunocytochemical analysis of primary HCL cases. These results have biological implications relevant to the pathogenesis of this malignancy as well as clinical implications for its diagnosis and therapy.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 14707115   Authors: Basso K,Liso A,Tiacci E,Benedetti R,Pulsoni A,Foa R,Di Raimondo F,Ambrosetti A,Califano A,Klein U,Dalla Favera R,Falini B
Exact source Table 4S; correspond to red color in Fig 4
Related gene sets (show 1 additional gene sets from the source publication)

(show 62 gene sets from any of these authors)
External links
Filtered by similarity ?
Source species Homo sapiens
Contributed by Arthur Liberzon (MSigDB Team)
Source platform or
identifier namespace		 AFFY_HG_U95
Dataset references  
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 79 genes
Gene families ? Categorize these 79 genes by gene family
Show members (show 88 source identifiers mapped to 79 genes)
Version history  

See MSigDB license terms here. Please note that certain gene sets have special access terms.