Human Gene Set: FOSTER_TOLERANT_MACROPHAGE_UP

For the Mouse gene set with the same name, see FOSTER_TOLERANT_MACROPHAGE_UP

Standard name FOSTER_TOLERANT_MACROPHAGE_UP
Systematic name M12676
Brief description Class T (tolerizable) genes: induced during the first LPS stimulation and not re-induced or induced to a much lesser degree in tolerant macrophages (as defined by (N+L)/(T+L) > 3).
Full description or abstract Toll-like receptors (TLRs) induce a multi-component inflammatory response that must be tightly regulated to avoid tissue damage. Most known regulatory mechanisms target TLR signalling pathways and thus broadly inhibit multiple aspects of the inflammatory response. Given the functional diversity of TLR-induced genes, we proposed that additional, gene-specific regulatory mechanisms exist to allow individual aspects of the TLR-induced response to be differentially regulated. Using an in vitro system of lipopolysaccharide tolerance in murine macrophages, we show that TLR-induced genes fall into two categories on the basis of their functions and regulatory requirements. We demonstrate that representatives from the two classes acquire distinct patterns of TLR-induced chromatin modifications. These gene-specific chromatin modifications are associated with transient silencing of one class of genes, which includes pro-inflammatory mediators, and priming of the second class, which includes antimicrobial effectors. These findings illustrate an adaptive response in macrophages and reveal component-specific regulation of inflammation.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 17538624   Authors: Foster SL,Hargreaves DC,Medzhitov R
Exact source Table 1S: Class T genes: (N+L)/(T+L) > 3
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Source species Mus musculus
Contributed by Jessica Robertson (MSigDB Team)
Source platform or
identifier namespace		 AFFY_Mouse430
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Version history 3.1: FOSTER_INFLAMMATORY_RESPONSE_LPS_UP


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