Human Gene Set: GENGQIU_LUAD_CAF_MARKER_GENES


Standard name GENGQIU_LUAD_CAF_MARKER_GENES
Systematic name M50217
Brief description Genes identifying cancer-associated fibroblasts (CAFs) and their associated tumor microenvironment (TME) remodeling activity in lung adenocarcinoma (LUAD), derived from integrated single-cell and bulk RNA-sequencing analysis.
Full description or abstract This gene set consists of 227 marker genes identified through a comprehensive integrated analysis of single-cell RNA sequencing (scRNA-seq) and bulk transcriptomic data in lung adenocarcinoma (LUAD). Using scRNA-seq data from the Gene Expression Omnibus (GEO), researchers isolated cancer-associated fibroblasts (CAFs) and identified these 227 genes as highly specific markers for the CAF population within the tumor microenvironment (TME).
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 40831319   Authors: Liu G,Feng J,Huang Y,Zhang J,Li Y
Exact source Supplemental Table 3, Supplemental Digital Content 4, https://links.lww.com/JIT/A999
Related gene sets (show 169 gene sets from any of these authors)
External links https://journals.lww.com/immunotherapy-journal/fulltext/2025/11000/integrated_analysis_...
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Source species Homo sapiens
Contributed by Anthony Castanza (MSigDB Team)
Source platform or
identifier namespace		 HUMAN_GENE_SYMBOL
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GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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Version history 2026.1.Hs: First Introduced.


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