Human Gene Set: GSE3203_UNTREATED_VS_IFNB_TREATED_LN_BCELL_DN


Standard name GSE3203_UNTREATED_VS_IFNB_TREATED_LN_BCELL_DN
Systematic name M6789
Brief description Genes down-regulated in lymph node B lymphocytes: untreated versus interferon beta.
Full description or abstract Influenza virus infection-induced gene expression changes of regional B cells are mediated at least in part through type I Interferon: Our objective is to determine whether the influenza virus-infection induced gene expression changes in regional lymph node B cells are facilitated at least in part through type I interferon. Our specific aim is to compare the gene expression profile of highly FACS-purified B cells in the regional lymph nodes of wildtype and IFNR-/- mice prior to and 48h following infection with influenza virus infection and to contrast this expression profile with that of FACS-purified wildtype B cells activated in vitro with IFN-beta +/- anti-CD86 for 12h.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 17237394   Authors: Chang WL,Coro ES,Rau FC,Xiao Y,Erle DJ,Baumgarth N
Exact source GSE3203_2809_200_DN
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Source species Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
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identifier namespace		 HUMAN_GENE_SYMBOL
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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