Human Gene Set: GSE44732_UNSTIM_VS_IL27_STIM_IMATURE_DC_DN


Standard name GSE44732_UNSTIM_VS_IL27_STIM_IMATURE_DC_DN
Systematic name M9700
Brief description Genes down-regulated in immature dendritic cells: untreated versus IL27 [GeneID=246778].
Full description or abstract IL-27 treated DCs were shown to be highly potent inhibitors of cis HIV-1, particularly of CCR5 tropic strains. Microarray studies of IL-27 treated DCs showed no up-regulation of Type I (IFN) gene expression. Neutralization of the Type-I IFN receptor had no impact on the HIV inhibition. Lastly, IL-27 mediated inhibition was shown to act post-viral entry and prior to completion of reverse transcription. These results show for the first time that IL-27 is a potent inhibitor of cis HIV-1 infection in DCs by a Type I IFN independent mechanism.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 23527130   Authors: Chen Q,Swaminathan S,Yang D,Dai L,Sui H,Yang J,Hornung RL,Wang Y,Huang da W,Hu X,Lempicki RA,Imamichi T
Exact source GSE44732_3800_200_DN
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Source species Homo sapiens
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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