Human Gene Set: KANAI_YAP_TAZ_UP


Standard name KANAI_YAP_TAZ_UP
Systematic name M50115
Brief description A set of genes that are up-regulated by YAP or TAZ in cancer cells and that are enriched in cancer cell lines that are dependent upon either YAP, TAZ or TEADs for cell viability.
Full description or abstract The YAP/TAZ-TEAD axis is activated and plays a causal role in several cancer types, and inhibitors that target this axis are currently in early phase clinical trials in cancer patients. However, mutations that predict YAP/TAZ-TEAD activation are not common in most cancers, making it hard to determine which tumors are likely to respond to these inhibitors. Here, we used a combination of RNA-seq and bioinformatics analysis of metastatic human melanoma cells to develop a YAP/TAZ gene signature. We found that the genes in this signature are TEAD-dependent in several melanoma cell lines, and that their expression strongly correlates with established YAP/TAZ target genes in human melanomas. Using DepMap dependency data, we found that the genes in this YAP/TAZ signature are highly expressed in YAP/TAZ or TEAD dependent melanoma cell lines and that this signature was predictive of melanoma cell dependence upon YAP/TAZ or TEADs. Importantly, this was not limited to melanoma because these genes are also regulated by YAP and TAZ in other cancer cell lines and this signature was predictive of YAP/TAZ-TEAD dependence when tested on a panel of over 1000 cancer cell lines. Our results suggest that this YAP/TAZ gene signature may be an effective tool to predict YAP/TAZ activation in cancer cells and could potentially be used to predict sensitivity to YAP/TAZ-TEAD inhibition.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 38473214   Authors: Kanai R,Norton E,Stern P,Hynes RO,Lamar JM
Exact source TABLE_S3_Tab6
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Source species Homo sapiens
Contributed by John M. Lamar (Albany Medical College)
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identifier namespace		 HUMAN_GENE_SYMBOL
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Version history 2025.1.Hs: First Introduced.

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