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Human Gene Set: KRAS.LUNG_UP.V1_DN
Standard name
KRAS.LUNG_UP.V1_DN
Systematic name
M2893
Brief description
Genes down-regulated in epithelial lung cancer cell lines over-expressing an oncogenic form of KRAS
[GeneID=3845]
gene.
Full description or abstract
Collection
C6: Oncogenic Signature
Source publication
Exact source
AALE-KRAS vs AALE-Vector: bot 150 genes (diff. of means). Similar to GSE17643: Broad KRAS internal signatures generated by J. Boehm.
Related gene sets
External links
Filtered by similarity
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Source species
Homo sapiens
Contributed by
Pablo Tamayo (Broad Institute)
Source platform or
identifier namespace
HUMAN_GENE_SYMBOL
Dataset references
Download gene set
format:
grp
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TSV metadata
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H: Hallmark
C1: Positional
C2: Curated
CGP: Chemical and Genetic Perturbations
CP: Canonical Pathways
CP:BIOCARTA: BioCarta Pathways
CP:KEGG_MEDICUS: KEGG Medicus Pathways
CP:PID: PID Pathways
CP:REACTOME: Reactome Pathways
CP:WIKIPATHWAYS: WikiPathways
CP:KEGG_LEGACY: KEGG Legacy Pathways
C3: Regulatory Target
MIR: microRNA Targets
MIR:MIRDB: miRDB
MIR:MIR_LEGACY: MIR_Legacy
TFT: Transcription Factor Targets
TFT:GTRD: GTRD
TFT:TFT_LEGACY: TFT_Legacy
C4: Computational
3CA: Curated Cancer Cell Atlas gene sets
CGN: Cancer Gene Neighborhoods
CM: Cancer Modules
C5: Ontology
GO: Gene Ontology
GO:BP: GO Biological Process
GO:CC: GO Cellular Component
GO:MF: GO Molecular Function
HPO: Human Phenotype Ontology
C6: Oncogenic Signature
C7: Immunologic Signature
IMMUNESIGDB: ImmuneSigDB
VAX: HIPC Vaccine Response
C8: Cell Type Signature
Compendia expression profiles
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NG-CHM interactive heatmaps
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Please note that clustering takes a few seconds
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GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query
Further investigate
these 143 genes
Gene families
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Categorize
these 143 genes by gene family
Show members
(
show
150 source identifiers mapped to 143 genes)
Source
Id
NCBI (Entrez)
Gene Id
Gene
Symbol
Gene
Description
ACHE
43
ACHE
acetylcholinesterase (...
ACPP
55
ACP3
acid phosphatase 3 [So...
ADD2
119
ADD2
adducin 2 [Source:HGNC...
ADORA3
140
ADORA3
adenosine A3 receptor ...
AKAP4
8852
AKAP4
A-kinase anchoring pro...
AKAP6
9472
AKAP6
A-kinase anchoring pro...
AKR1B10
57016
AKR1B10
aldo-keto reductase fa...
ALDH3B2
222
ALDH3B2
aldehyde dehydrogenase...
APOBEC3A
200315
APOBEC3A
apolipoprotein B mRNA ...
BBC3
27113
BBC3
BCL2 binding component...
BBOX1
8424
BBOX1
gamma-butyrobetaine hy...
C14orf140
79696
ZC2HC1C
zinc finger C2HC-type ...
C1R /// LOC64367
6
C6orf134
79969
ATAT1
alpha tubulin acetyltr...
C6orf64
55776
SAYSD1
SAYSVFN motif domain c...
CABP3 /// CABP5
CACNA1F
778
CACNA1F
calcium voltage-gated ...
CALML3
810
CALML3
calmodulin like 3 [Sou...
CALML5
51806
CALML5
calmodulin like 5 [Sou...
CBL
867
CBL
Cbl proto-oncogene [So...
CCDC132
55610
VPS50
VPS50 subunit of EARP/...
CCR2
729230
CCR2
C-C motif chemokine re...
CD248
57124
CD248
CD248 molecule [Source...
CDH12
1010
CDH12
cadherin 12 [Source:HG...
CDH16
1014
CDH16
cadherin 16 [Source:HG...
CDKN1C
1028
CDKN1C
cyclin dependent kinas...
CHRM5
1133
CHRM5
cholinergic receptor m...
CLCA4
22802
CLCA4
chloride channel acces...
COBL
23242
COBL
cordon-bleu WH2 repeat...
COL19A1
1310
COL19A1
collagen type XIX alph...
COL2A1
1280
COL2A1
collagen type II alpha...
CRABP2
1382
CRABP2
cellular retinoic acid...
CRYAB
1410
CRYAB
crystallin alpha B [So...
CXCL14
9547
CXCL14
C-X-C motif chemokine ...
CYP26B1
56603
CYP26B1
cytochrome P450 family...
CYP2C18
1562
CYP2C18
cytochrome P450 family...
CYP4B1
1580
CYP4B1
cytochrome P450 family...
DEFB1
1672
DEFB1
defensin beta 1 [Sourc...
DKFZp434A0131
54441
STAG3L1
STAG3 cohesin complex ...
EMID1
129080
EMID1
EMI domain containing ...
EPHB3
2049
EPHB3
EPH receptor B3 [Sourc...
ERG
2078
ERG
ETS transcription fact...
FCGR3B
2215
FCGR3B
Fc gamma receptor IIIb...
FLJ22531
79703
TOP6BL
TOP6B like initiator o...
FLJ22814
933
CD22
CD22 molecule [Source:...
FMO2
2327
FMO2
flavin containing dime...
GABRB1
2560
GABRB1
gamma-aminobutyric aci...
GALNT8
26290
GALNT8
polypeptide N-acetylga...
GAS1
2619
GAS1
growth arrest specific...
GDNF
2668
GDNF
glial cell derived neu...
GLYAT
10249
GLYAT
glycine-N-acyltransfer...
GPNMB
10457
GPNMB
glycoprotein nmb [Sour...
GPR45
11250
GPR45
G protein-coupled rece...
HAAO
23498
HAAO
3-hydroxyanthranilate ...
HEY2
23493
HEY2
hes related family bHL...
HTR1B
3351
HTR1B
5-hydroxytryptamine re...
HTR1D
3352
HTR1D
5-hydroxytryptamine re...
IGFBP2
3485
IGFBP2
insulin like growth fa...
IHH
3549
IHH
Indian hedgehog signal...
IL10RA
3587
IL10RA
interleukin 10 recepto...
INPP5D
3635
INPP5D
inositol polyphosphate...
IVL
3713
IVL
involucrin [Source:HGN...
KIAA1305
57523
NYNRIN
NYN domain and retrovi...
KLK11
11012
KLK11
kallikrein related pep...
KLK12
43849
KLK12
kallikrein related pep...
KLK7
5650
KLK7
kallikrein related pep...
KLK8
11202
KLK8
kallikrein related pep...
KRT1
3848
KRT1
keratin 1 [Source:HGNC...
KRT13
3860
KRT13
keratin 13 [Source:HGN...
KRT15
3866
KRT15
keratin 15 [Source:HGN...
KRT16
3868
KRT16
keratin 16 [Source:HGN...
KRT4
3851
KRT4
keratin 4 [Source:HGNC...
LGALS7
3963
LGALS7
galectin 7 [Source:HGN...
LGP2
79132
DHX58
DExH-box helicase 58 [...
LMO1
4004
LMO1
LIM domain only 1 [Sou...
LOC283079
100507605
LINC00837
long intergenic non-pr...
LOC286526
282808
RAB40AL
RAB40A like [Source:HG...
LOC339457
85452
CFAP74
cilia and flagella ass...
LOC440895
440895
ENSG00000290731
novel transcript
LOC57399
LOC643641
643641
ZNF862
zinc finger protein 86...
LOC653326
LY6D
8581
LY6D
lymphocyte antigen 6 f...
LYPD3
27076
LYPD3
LY6/PLAUR domain conta...
MAFB
9935
MAFB
MAF bZIP transcription...
MAP2K6
5608
MAP2K6
mitogen-activated prot...
MAP3K1
4214
MAP3K1
mitogen-activated prot...
MC5R
4161
MC5R
melanocortin 5 recepto...
MEGF8
1954
MEGF8
multiple EGF like doma...
METTL7A
25840
TMT1A
thiol methyltransferas...
MORC1
27136
MORC1
MORC family CW-type zi...
MST1 /// MSTP9
MXRA8
54587
MXRA8
matrix remodeling asso...
NGFR
4804
NGFR
nerve growth factor re...
OLFML2A
169611
OLFML2A
olfactomedin like 2A [...
OR3A3
8392
OR3A3
olfactory receptor fam...
P53AIP1 /// LOC6
4858
PALM
5064
PALM
paralemmin [Source:HGN...
PDE6B
5158
PDE6B
phosphodiesterase 6B [...
PIK3C2B
5287
PIK3C2B
phosphatidylinositol-4...
PLA2G10
8399
PLA2G10
phospholipase A2 group...
PLCH2
9651
PLCH2
phospholipase C eta 2 ...
POSTN
10631
POSTN
periostin [Source:HGNC...
PPFIBP2
8495
PPFIBP2
PPFIA binding protein ...
PPYR1
5540
NPY4R
neuropeptide Y recepto...
PROC
5624
PROC
protein C, inactivator...
PRODH
5625
PRODH
proline dehydrogenase ...
PROM1
8842
PROM1
prominin 1 [Source:HGN...
PSG7
5676
PSG7
pregnancy specific bet...
PSORS1C1
170679
PSORS1C1
psoriasis susceptibili...
PTPRU
10076
PTPRU
protein tyrosine phosp...
RAG1
5896
RAG1
recombination activati...
RDH16
8608
RDH16
retinol dehydrogenase ...
RHCG
51458
RHCG
Rh family C glycoprote...
RTP4
64108
RTP4
receptor transporter p...
RYR1
6261
RYR1
ryanodine receptor 1 [...
S100A12
6283
S100A12
S100 calcium binding p...
S100A7
6278
S100A7
S100 calcium binding p...
SCARF1
8578
SCARF1
scavenger receptor cla...
SCGB1A1
7356
SCGB1A1
secretoglobin family 1...
SCN10A
6336
SCN10A
sodium voltage-gated c...
SCRG1
11341
SCRG1
stimulator of chondrog...
SERPINB13
5275
SERPINB13
serpin family B member...
SERPINB3
6317
SERPINB3
serpin family B member...
SERPINB4
6318
SERPINB4
serpin family B member...
SGCD
6444
SGCD
sarcoglycan delta [Sou...
SH3BP1
23616
SH3BP1
SH3 domain binding pro...
SH3GL3
6457
SH3GL3
SH3 domain containing ...
SLC39A2
29986
SLC39A2
solute carrier family ...
SLC3A1
6519
SLC3A1
solute carrier family ...
SLC6A14
11254
SLC6A14
solute carrier family ...
SLC6A9
6536
SLC6A9
solute carrier family ...
SOX30
11063
SOX30
SRY-box transcription ...
SPRR3
6707
SPRR3
small proline rich pro...
SPTBN2
6712
SPTBN2
spectrin beta, non-ery...
SRD5A2L
79644
SRD5A3
steroid 5 alpha-reduct...
TF
7018
TF
transferrin [Source:HG...
TGM1
7051
TGM1
transglutaminase 1 [So...
THAP9
79725
THAP9
THAP domain containing...
TNFSF10
8743
TNFSF10
TNF superfamily member...
TRGV7
6981
TRGV7
T cell receptor gamma ...
TRHDE
29953
TRHDE
thyrotropin releasing ...
TRIM48
79097
TRIM48
tripartite motif conta...
TSC22D4
81628
TSC22D4
TSC22 domain family me...
TTTY9A /// TTTY9
B
UPK3B
105375355
UPK3B
uroplakin 3B [Source:H...
VAV3
10451
VAV3
vav guanine nucleotide...
VPREB1
7441
VPREB1
V-set pre-B cell surro...
WNT16
51384
WNT16
Wnt family member 16 [...
ZNF750
79755
ZNF750
zinc finger protein 75...
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