Human Gene Set: LIANG_PANCREATIC_CANCER_DENDRITIC_CELL_GENES


Standard name LIANG_PANCREATIC_CANCER_DENDRITIC_CELL_GENES
Systematic name M50220
Brief description 20 genes exhibiting Hazard Ratios >1 of the 22 genes significantly associated with overall survival in the TCGA-PDAC training Cohort by univariate Cox regression. Higher expression of this gene set is associated worse overall survival.
Full description or abstract This gene set comprises 22 dendritic cell-related genes identified from WGCNA modules correlated with dendritic cell infiltration in pancreatic ductal adenocarcinoma cohorts. The genes were selected based on their association with overall survival and DC-related expression patterns. Using these genes, unsupervised consensus clustering stratified TCGA-PAAD patients into cluster 1 and cluster 2. The authors report that cluster 2 exhibited higher expression of DC-related genes and significantly poorer overall survival, whereas cluster 1 showed lower expression and better survival. These genes were further used to derive a dendritic cell-related risk score (DCRS). Patients with a high DCRS (corresponding to cluster 2) had significantly worse overall survival than those with a low DCRS (corresponding to cluster 1).
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 41080575   Authors: Liang Y,Gu Y,Zhang Z,Zhong D,Yan H,Su Y,Chen Y,Wang F,Leng Z,Huang X
Exact source Data Sheet 1, Figure S2. Selected Genes exhibiting a Hazard Ratio >1 (20/22 genes). GNG7 and CD81 were excluded on this basis.
Related gene sets (show 2513 gene sets from any of these authors)
External links https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1665906/full
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Source species Homo sapiens
Contributed by Anthony Castanza (MSigDB Team)
Source platform or
identifier namespace		 HUMAN_GENE_SYMBOL
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NCI-60 cell lines (National Cancer Institute)
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Version history 2026.1.Hs: First Introduced.


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