Human Gene Set: LI_STAD_HIGH_RISK_UP


Standard name LI_STAD_HIGH_RISK_UP
Systematic name M50223
Brief description Genes significantly upregulated in high-risk STAD patients based on the ADCP signature.
Full description or abstract From Table S2 of Wang et al., 2025, these genes were upregulated (adjusted p ? 0.05) in patients classified as high-risk by the 27-gene ADCP-related signature. High-risk patients exhibit poorer overall survival, lower CD8? T cell, monocyte, and neutrophil infiltration, higher plasma cell numbers, and decreased expression of key immune checkpoint and HLA genes. Upregulated genes are enriched in pathways including vasopressin-regulated water reabsorption, glycosaminoglycan biosynthesis, keratan sulfate metabolism, and non-homologous end-joining, potentially reflecting more aggressive tumor biology and altered immune regulation.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 40193680   Authors: Li X,Wang H,Li X,Zeng M,He Z,Song L,Chen Z,Tang X,Wang A
Exact source md_2025_03_21_wang_md-d-23-10653_sdc2. Table S2 DEGs between high-risk and low-risk groups. Genes with an adjusted_pvalue <= 0.05 and annotated as Significant Up
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External links https://doi.org/10.1097/MD.0000000000042079
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Source species Homo sapiens
Contributed by Anthony Castanza (MSigDB Team)
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identifier namespace		 HUMAN_GENE_SYMBOL
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Version history 2026.1.Hs: First Introduced.


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