Human Gene Set: ACEVEDO_FGFR1_TARGETS_IN_PROSTATE_CANCER_MODEL_DN

Standard name

ACEVEDO_FGFR1_TARGETS_IN_PROSTATE_CANCER_MODEL_DN

Systematic name

M2571

Brief description

Genes down-regulated during prostate cancer progression in the JOCK1 model due to inducible activation of FGFR1 [GeneID=2260] gene in prostate.

Full description or abstract

Fibroblast Growth Factor Receptor-1 (FGFR1) is commonly overexpressed in advanced prostate cancer (PCa). To investigate causality, we utilized an inducible FGFR1 (iFGFR1) prostate mouse model. Activation of iFGFR1 with chemical inducers of dimerization (CID) led to highly synchronous, step-wise progression to adenocarcinoma that is linked to an epithelial-to-mesenchymal transition (EMT). iFGFR1 inactivation by CID withdrawal led to full reversion of prostatic intraepithelial neoplasia, whereas PCa lesions became iFGFR1-independent. Gene expression profiling at distinct stages of tumor progression revealed an increase in EMT-associated Sox9 and changes in the Wnt signaling pathway, including Fzd4, which was validated in human PCa. The iFGFR1 model clearly implicates FGFR1 in PCa progression and demonstrates how CID-inducible models can help evaluate candidate molecules in tumor progression and maintenance.

Collection

ARCHIVED: Archived Founder gene sets that are referenced by current Hallmarks
C2_NONE: ARCHIVED Curated
C2_CGP: ARCHIVED Chemical and Genetic Perturbations

Source publication

Pubmed 18068632 Authors: Acevedo VD,Gangula RD,Freeman KW,Li R,Zhang Y,Wang F,Ayala GE,Peterson LE,Ittmann M,Spencer DM

Exact source

Table 1S: Avg. fold change < 1

Related gene sets

(show 1 additional gene sets from the source publication)

(show 99 gene sets from any of these authors)

External links

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Source species

Mus musculus

Contributed by

Yujin Hoshida (Broad Institute)

Source platform or
identifier namespace

UniGene_ID

Dataset references

(show 1 datasets)

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format: grp | gmt | xml | json | TSV metadata

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Show members

(show 354 source identifiers mapped to 0 genes)

Source Id	NCBI (Entrez) Gene Id	Gene Symbol	Gene Description
Mm.100167
Mm.10099
Mm.102436
Mm.103810
Mm.1055
Mm.10661
Mm.10694
Mm.10753
Mm.10929
Mm.1100
Mm.117294
Mm.118804
Mm.118845
Mm.121878
Mm.122091
Mm.1225
Mm.124567
Mm.125874
Mm.127731
Mm.128733
Mm.131001
Mm.132167
Mm.133687
Mm.135815
Mm.136736
Mm.136889
Mm.140768
Mm.141936
Mm.14269
Mm.144300
Mm.146332
Mm.147208
Mm.147226
Mm.151171
Mm.151962
Mm.153429
Mm.154093
Mm.154486
Mm.155586
Mm.156558
Mm.157697
Mm.158272
Mm.158903
Mm.16340
Mm.16497
Mm.16831
Mm.1716
Mm.173392
Mm.17771
Mm.178427
Mm.178798
Mm.17964
Mm.180124
Mm.181074
Mm.18213
Mm.183314
Mm.18590
Mm.186185
Mm.187830
Mm.188108
Mm.18832
Mm.188339
Mm.188516
Mm.192991
Mm.19325
Mm.196189
Mm.196208
Mm.196239
Mm.196484
Mm.1977
Mm.19958
Mm.200423
Mm.200916
Mm.201493
Mm.206417
Mm.208144
Mm.20851
Mm.20894
Mm.209283
Mm.20929
Mm.210567
Mm.210815
Mm.21109
Mm.213025
Mm.2131
Mm.214514
Mm.214950
Mm.217171
Mm.21787
Mm.218957
Mm.220170
Mm.221412
Mm.22144
Mm.22216
Mm.222320
Mm.222329
Mm.22256
Mm.226284
Mm.22701
Mm.227443
Mm.232930
Mm.233117
Mm.2343
Mm.234441
Mm.234783
Mm.23551
Mm.235975
Mm.24142
Mm.2416
Mm.24210
Mm.24551
Mm.24564
Mm.24663
Mm.247265
Mm.247426
Mm.247956
Mm.250023
Mm.250185
Mm.250256
Mm.250705
Mm.25089
Mm.252417
Mm.252481
Mm.252514
Mm.254493
Mm.25471
Mm.25539
Mm.255607
Mm.255909
Mm.256488
Mm.25722
Mm.259191
Mm.259333
Mm.259498
Mm.259516
Mm.259626
Mm.259852
Mm.261329
Mm.26150
Mm.261601
Mm.263189
Mm.263514
Mm.26361
Mm.26513
Mm.266033
Mm.26930
Mm.270469
Mm.27154
Mm.27159
Mm.271668
Mm.271770
Mm.271976
Mm.272037
Mm.27208
Mm.272197
Mm.272290
Mm.272321
Mm.272368
Mm.272582
Mm.273087
Mm.273108
Mm.273271
Mm.273785
Mm.274158
Mm.27469
Mm.274995
Mm.275639
Mm.275648
Mm.276831
Mm.277518
Mm.277939
Mm.277955
Mm.27943
Mm.279690
Mm.28015
Mm.281124
Mm.281738
Mm.281844
Mm.282900
Mm.283273
Mm.283281
Mm.283283
Mm.28638
Mm.286394
Mm.287014
Mm.287146
Mm.28935
Mm.289441
Mm.289645
Mm.2900
Mm.290149
Mm.29140
Mm.29148
Mm.291783
Mm.292560
Mm.292865
Mm.29395
Mm.2942
Mm.29482
Mm.295397
Mm.295441
Mm.295533
Mm.295539
Mm.29619
Mm.296532
Mm.296889
Mm.29780
Mm.29815
Mm.298251
Mm.298256
Mm.299
Mm.3019
Mm.304264
Mm.305108
Mm.307966
Mm.308134
Mm.30832
Mm.30837
Mm.309617
Mm.310551
Mm.310635
Mm.311655
Mm.312095
Mm.3126
Mm.31274
Mm.3193
Mm.320206
Mm.321147
Mm.32416
Mm.3248
Mm.32562
Mm.325757
Mm.327088
Mm.3283
Mm.32831
Mm.328503
Mm.329299
Mm.329322
Mm.329784
Mm.330351
Mm.330731
Mm.330770
Mm.331349
Mm.331573
Mm.332128
Mm.332257
Mm.332293
Mm.332919
Mm.333375
Mm.333406
Mm.33360
Mm.336245
Mm.33645
Mm.336519
Mm.336625
Mm.339846
Mm.340077
Mm.340132
Mm.341103
Mm.34171
Mm.342686
Mm.343899
Mm.344148
Mm.34459
Mm.3459
Mm.34695
Mm.347546
Mm.347711
Mm.347910
Mm.34797
Mm.35199
Mm.354720
Mm.355601
Mm.35817
Mm.358643
Mm.358954
Mm.370334
Mm.371562
Mm.371675
Mm.373417
Mm.376046
Mm.37666
Mm.377091
Mm.378109
Mm.378137
Mm.37817
Mm.378882
Mm.378954
Mm.379020
Mm.379254
Mm.379282
Mm.38009
Mm.38271
Mm.383209
Mm.383285
Mm.383993
Mm.38498
Mm.386767
Mm.386769
Mm.386842
Mm.38933
Mm.39101
Mm.3925
Mm.40447
Mm.4103
Mm.41044
Mm.41113
Mm.41708
Mm.41981
Mm.42012
Mm.42103
Mm.42242
Mm.4258
Mm.4356
Mm.44075
Mm.443
Mm.45127
Mm.45191
Mm.46254
Mm.4686
Mm.4776
Mm.4913
Mm.4920
Mm.4952
Mm.4954
Mm.49689
Mm.49728
Mm.4974
Mm.4987
Mm.5023
Mm.52319
Mm.5341
Mm.54306
Mm.57225
Mm.60526
Mm.6200
Mm.6250
Mm.646
Mm.6529
Mm.65457
Mm.65691
Mm.6712
Mm.681
Mm.6813
Mm.69566
Mm.6974
Mm.74324
Mm.754
Mm.79127
Mm.8032
Mm.86870
Mm.89564
Mm.89655
Mm.94160

Version history

3.1: First introduced

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