Human Gene Set: AKT_UP.V1_DN

Standard name AKT_UP.V1_DN
Systematic name M2666
Brief description Genes down-regulated in mouse prostate by transgenic expression of human AKT1 gene [GeneID=207] vs controls.
Full description or abstract Transgenic (Probasin driven Myr-AKT) or wild-type littermates were treated with RAD001 or placebo and sacrificed at 12 and 48 h following the beginning of treatment.
Collection C6: Oncogenic Signature
Source publication Pubmed 15156201   Authors: Majumder PK,Febbo PG,Bikoff R,Berger R,Xue Q,McMahon LM,Manola J,Brugarolas J,McDonnell TJ,Golub TR,Loda M,Lane HA,Sellers WR
Exact source AKT_PLACEBO vs WT_PLACEBO; bottom 150 genes (diff. of means)
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(show 271 gene sets from the same authors)
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Source species Mus musculus
Contributed by Pablo Tamayo (Broad Institute)
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Compendia expression profiles ? GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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Version history 7.1: Fixed RIKEN identifiers.

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