Human Gene Set: AMIT_DELAYED_EARLY_GENES


Standard name AMIT_DELAYED_EARLY_GENES
Systematic name M10550
Brief description Delayed early genes (DEG) which are coordinately down-regulated in multiple epithelial tumor types.
Full description or abstract Signaling pathways invoke interplays between forward signaling and feedback to drive robust cellular response. In this study, we address the dynamics of growth factor signaling through profiling of protein phosphorylation and gene expression, demonstrating the presence of a kinetically defined cluster of delayed early genes that function to attenuate the early events of growth factor signaling. Using epidermal growth factor receptor signaling as the major model system and concentrating on regulation of transcription and mRNA stability, we demonstrate that a number of genes within the delayed early gene cluster function as feedback regulators of immediate early genes. Consistent with their role in negative regulation of cell signaling, genes within this cluster are downregulated in diverse tumor types, in correlation with clinical outcome. More generally, our study proposes a mechanistic description of the cellular response to growth factors by defining architectural motifs that underlie the function of signaling networks.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 17322878   Authors: Amit I,Citri A,Shay T,Lu Y,Katz M,Zhang F,Tarcic G,Siwak D,Lahad J,Jacob-Hirsch J,Amariglio N,Vaisman N,Segal E,Rechavi G,Alon U,Mills GB,Domany E,Yarden Y
Exact source Fig 5a
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Source species Homo sapiens
Contributed by Arthur Liberzon (MSigDB Team)
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identifier namespace		 HUMAN_GENE_SYMBOL
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Version history 3.0: First introduced

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