Gene Set: APRELIKOVA_BRCA1_TARGETS

Standard name APRELIKOVA_BRCA1_TARGETS
Systematic name M1568
Brief description Genes down-regulated in embryonic stem cells with BRCA1 [GeneID=672] loss of function (LOF).
Full description or abstract BRCA1 gene is a tumor suppressor for breast and ovarian cancers with the putative role in DNA repair and transcription. To characterize the role of BRCA1 in transcriptional regulation, we analyzed gene expression profiles of mouse embryonic stem cells deficient in BRCA1 using microarray technology. We found that loss of BRCA1 correlated with decreased expression of several groups of genes including stress response genes, cytoskeleton genes, and genes involved in protein synthesis and degradation. Previous study showed that BRCA1 is a transcriptional co-activator of p53 protein; however the majority of p53 target genes remained at the same expression levels in BRCA1 knockout cells as in the wild type cells. The only p53 target gene down-regulated with the loss of BRCA1 was 14-3-3 sigma, a major G(2)/M checkpoint control gene. Similar to cells with decreased 14-3-3 sigma activity, BRCA1-deficient cells were unable to sustain G(2)/M growth arrest after exposure to ionizing radiation. We find that BRCA1 induction of 14-3-3 sigma requires the presence of wild type p53 and can be regulated by a minimal p53 response element.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 11384963   Authors: Aprelikova O,Pace AJ,Fang B,Koller BH,Liu ET
Exact source Table 1S
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Organism Mus musculus
Contributed by John Newman (University of Washington)
Source platform MOUSE_SEQ_ACCESSION
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Version history 3.1: First introduced

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