Systematic name M2311
Brief description Genes down-regulated in RWPE-1 cells (prostate cancer) upon expression of constitutively active form of STAT3 [GeneID=6774].
Full description or abstract The persistent activation of signal transducer and activator of transcription 3 (Stat3) is a common feature of prostate cancer. However, little is known about the Stat3 targets that may mediate prostate tumorigenesis. The introduction of an activating mutant form of Stat3 (Stat3-C) into immortalized prostate epithelial cells resulted in tumorigenesis. Stat3-C-expressing cells had decreased E-cadherin levels, increased numbers of lamellipodia and stress fibers, and enhanced migratory capacities compared to vector control-expressing cells, with a concomitant increase in the expression of integrin beta6 and its ligand, fibronectin (FN). Exogenously added FN increased cellular migration, with a concomitant loss of E-cadherin expression. The blockade of integrin alphavbeta6 in Stat3-C-expressing cells inhibited migration, increased E-cadherin levels, and reduced colony formation in soft agar. These results demonstrate the sufficiency of constitutively activated Stat3 in mediating prostate tumorigenesis and identify novel Stat3 targets that are involved in promoting cell migration and transformation.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 17438134   Authors: Azare J,Leslie K,Al-Ahmadie H,Gerald W,Weinreb PH,Violette SM,Bromberg J
Exact source Table 1S: Fold Change > 0
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(show 5 gene sets from the same authors)
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Source species Homo sapiens
Contributed by Arthur Liberzon (MSigDB Team)
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