Gene Set: BIOCARTA_BAD_PATHWAY

Standard name BIOCARTA_BAD_PATHWAY
Systematic name M85
Brief description Regulation of BAD phosphorylation
Full description or abstract The function of the pro-apoptotic molecule BAD is regulated by phosphorylation of three sites (ser 112,136 and 155). Phosphorylation at these sites results in loss of the ability of BAD to heterodimerize with the survival proteins BCL-XL or BCL-2. Phosphorylated BAD binds to 14-3-3 and is sequestered in the cytoplasm. While ser-136 phosphorylation is concordant with the activation of Akt, Ser-112 phosphorylation requires activation of the Ras-MAPK pathway. BAD Ser 155 was found to be a major site of phosphorylation induced following stimulation by growth factors and prevented by protein kinase A inhibitors.
Collection C2: curated gene sets
      CP: canonical pathways
            CP:BIOCARTA: BioCarta gene sets
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External links https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/human/h_badPathway.gif
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Organism Homo sapiens
Contributed by BioCarta
Source platform HUMAN_SEQ_ACCESSION
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Version history 7.0: Changed members. Upgraded to final version of Biocarta.

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