Gene Set: BIOCARTA_ERK_PATHWAY

Standard name BIOCARTA_ERK_PATHWAY
Systematic name M287
Brief description Erk1/Erk2 Mapk Signaling pathway
Full description or abstract The p44/42 MAP Kinase pathway consists of a protein kinase cascade linking growth and differentiation signals with transcription in the nucleus. Growth factor receptors and tyrosine kinases activate Ras which in turn activates c-Raf, MEK, and MAP kinase. Activated p44/42 MAP Kinase translocates to the nucleus and activates transcription by phosphorylation of kinases such as p90 RSK, MSK, and transcription factors such as ELK-1 and Stat3. The importance of this pathway in both growth control and development has been demonstrated via the transforming properties of various mutant forms of Ras, Raf, MEK and by their effects on development. Signal amplification and the potential for crosstalk appear to be important features of this regulatory network.
Collection C2: curated gene sets
      CP: canonical pathways
            CP:BIOCARTA: BioCarta gene sets
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External links https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/human/h_erkPathway.gif
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Organism Homo sapiens
Contributed by BioCarta
Source platform HUMAN_SEQ_ACCESSION
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Compendia expression profiles GTEx compendium
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Version history 7.0: Changed members. Upgraded to final version of Biocarta.

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