Gene Set: BIOCARTA_TCAPOPTOSIS_PATHWAY

Standard name BIOCARTA_TCAPOPTOSIS_PATHWAY
Systematic name M16519
Brief description HIV Induced T Cell Apoptosis
Full description or abstract HIV infection is associated with immunosuppression caused by a dramatic reduction in the helper T cell population. The loss of helper T cells may be caused by HIV-induced apoptosis of both infected and uninfected helper T cells. HIV uses the CCR5 chemokine receptor as a coreceptor for macrophage cell entry and upregulates fas-ligand on these cells. CD4 on helper T cells is essential for viral cell entry and infection. Cross-linking of CD4 on the T cell surface may be involved in upregulation of Fas and sensitization of T cells to apoptosis induced by the Fas/Fas-ligand interaction.
Collection C2: curated gene sets
      CP: canonical pathways
            CP:BIOCARTA: BioCarta gene sets
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External links https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/human/h_tcapoptosisPathway.gif
Filtered by similarity
Organism Homo sapiens
Contributed by BioCarta
Source platform Human_RefSeq
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Compendia expression profiles GTEx compendium
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Global Cancer Map (Broad Institute)
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Version history 7.0: Changed members. Upgraded to final version of Biocarta.

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