Human Gene Set: BIOCARTA_TCAPOPTOSIS_PATHWAY
For the Mouse gene set with the same name, see BIOCARTA_TCAPOPTOSIS_PATHWAY
Standard name
BIOCARTA_TCAPOPTOSIS_PATHWAY
Systematic name
M16519
Brief description
HIV Induced T Cell Apoptosis
Full description or abstract
HIV infection is associated with immunosuppression caused by a dramatic reduction in the helper T cell population. The loss of helper T cells may be caused by HIV-induced apoptosis of both infected and uninfected helper T cells. HIV uses the CCR5 chemokine receptor as a coreceptor for macrophage cell entry and upregulates fas-ligand on these cells. CD4 on helper T cells is essential for viral cell entry and infection. Cross-linking of CD4 on the T cell surface may be involved in upregulation of Fas and sensitization of T cells to apoptosis induced by the Fas/Fas-ligand interaction.
Collection
C2: Curated CP: Canonical Pathways CP:BIOCARTA: BioCarta Pathways
Source publication
Exact source
Related gene sets
External links
https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/human/h_tcapoptosisPathway.gif
Filtered by similarity ?
Source species
Homo sapiens
Contributed by
BioCarta
Source platform or identifier namespace
Human_RefSeq
Dataset references
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these 9 genes
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9 genes by gene family
Show members
(show 20 source identifiers mapped to 9 genes)
Source Id
NCBI (Entrez) Gene Id
Gene Symbol
Gene Description
NM_000043
355
FAS
Fas cell surface death receptor [Source:H...
NM_000073
917
CD3G
CD3 gamma subunit of T-cell receptor comp...
NM_000579
1234
CCR5
C-C motif chemokine receptor 5 [Source:HG...
NM_000616
920
CD4
CD4 molecule [Source:HGNC Symbol;Acc:HGNC...
NM_000639
356
FASLG
Fas ligand [Source:HGNC Symbol;Acc:HGNC:1...
NM_000732
915
CD3D
CD3 delta subunit of T-cell receptor comp...
NM_000733
916
CD3E
CD3 epsilon subunit of T-cell receptor co...
NM_000734
919
CD247
CD247 molecule [Source:HGNC Symbol;Acc:HG...
NM_001040651
915
CD3D
CD3 delta subunit of T-cell receptor comp...
NM_001100168
1234
CCR5
C-C motif chemokine receptor 5 [Source:HG...
NM_001195014
920
CD4
CD4 molecule [Source:HGNC Symbol;Acc:HGNC...
NM_001195015
920
CD4
CD4 molecule [Source:HGNC Symbol;Acc:HGNC...
NM_001195016
920
CD4
CD4 molecule [Source:HGNC Symbol;Acc:HGNC...
NM_001195017
920
CD4
CD4 molecule [Source:HGNC Symbol;Acc:HGNC...
NM_001243077
940
CD28
CD28 molecule [Source:HGNC Symbol;Acc:HGN...
NM_001243078
940
CD28
CD28 molecule [Source:HGNC Symbol;Acc:HGN...
NM_006139
940
CD28
CD28 molecule [Source:HGNC Symbol;Acc:HGN...
NM_152871
355
FAS
Fas cell surface death receptor [Source:H...
NM_152872
355
FAS
Fas cell surface death receptor [Source:H...
NM_198053
919
CD247
CD247 molecule [Source:HGNC Symbol;Acc:HG...
Version history
7.0: Changed members. Upgraded to final version of Biocarta.
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