Human Gene Set: CHEOK_RESPONSE_TO_HD_MTX_DN


Standard name CHEOK_RESPONSE_TO_HD_MTX_DN
Systematic name M4535
Brief description Genes specifically down-regulated in pediatric acute lymphoblastic leukemia (ALL) patients by high-dose methotrexate (HDMTX) [PubChem=4112].
Full description or abstract To elucidate the genomics of cellular responses to cancer treatment, we analyzed the expression of over 9,600 human genes in acute lymphoblastic leukemia cells before and after in vivo treatment with methotrexate and mercaptopurine given alone or in combination. Based on changes in gene expression, we identified 124 genes that accurately discriminated among the four treatments. Discriminating genes included those involved in apoptosis, mismatch repair, cell cycle control and stress response. Only 14% of genes that changed when these medications were given as single agents also changed when they were given together. These data indicate that lymphoid leukemia cells of different molecular subtypes share common pathways of genomic response to the same treatment, that changes in gene expression are treatment-specific and that gene expression can illuminate differences in cellular response to drug combinations versus single agents.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 12704389   Authors: Cheok MH,Yang W,Pui CH,Downing JR,Cheng C,Naeve CW,Relling MV,Evans WE
Exact source Table 2S: HD DC < 0 & HD p val. < 0.01
Related gene sets (show 7 additional gene sets from the source publication)

(show 58 gene sets from any of these authors)
External links
Filtered by similarity ?
Source species Homo sapiens
Contributed by Jean Junior (MSigDB Team)
Source platform or
identifier namespace		 AFFY_HG_U95
Dataset references (show 1 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 23 genes
Gene families ? Categorize these 23 genes by gene family
Show members (show 25 source identifiers mapped to 23 genes)
Version history 3.0: Renamed from CHEOK_HDMTX_DN

See MSigDB license terms here. Please note that certain gene sets have special access terms.