Systematic name M609
Brief description Genes down-regulated in adult T-cell leukemia (ATL), chronic vs acute clinical condition.
Full description or abstract Adult T-cell leukemia (ATL) is an intractable malignancy of CD4+ T cells that is etiologically associated with infection by human T-cell leukemia virus-type I. Most individuals in the chronic stage of ATL eventually undergo progression to a highly aggressive acute stage. To clarify the mechanism responsible for this stage progression, we isolated CD4+ cells from individuals in the chronic (n=19) or acute (n=22) stages of ATL and subjected them to profiling of gene expression with DNA microarrays containing >44,000 probe sets. Changes in chromosome copy number were also examined for 24 cell specimens with the use of microarrays harboring approximately 50,000 probe sets. Stage-dependent changes in gene expression profile and chromosome copy number were apparent. Furthermore, expression of the gene for MET, a receptor tyrosine kinase for hepatocyte growth factor (HGF), was shown to be specific to the acute stage of ATL, and the plasma concentration of HGF was increased in individuals in either the acute or chronic stage. HGF induced proliferation of a MET-positive ATL cell line, and this effect was blocked by antibodies to HGF. The HGF-MET signaling pathway is thus a potential therapeutic target for ATL.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 16909099   Authors: Choi YL,Tsukasaki K,O'Neill MC,Yamada Y,Onimaru Y,Matsumoto K,Ohashi J,Yamashita Y,Tsutsumi S,Kaneda R,Takada S,Aburatani H,Kamihira S,Nakamura T,Tomonaga M,Mano H
Exact source Table 2S: up in acute
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Source species Homo sapiens
Contributed by Arthur Liberzon (MSigDB Team)
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Version history 3.0: First introduced

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