Gene Set: CHYLA_CBFA2T3_TARGETS_UP

Standard name CHYLA_CBFA2T3_TARGETS_UP
Systematic name M2205
Brief description Genes up-regulated in immature bone marrow progenitor cells upon knock out of CBFA2T3 [GeneID=863].
Full description or abstract While a number of DNA binding transcription factors have been identified that control hematopoietic cell fate decisions, only a limited number of transcriptional corepressors (e.g., the retinoblastoma protein [pRB] and the nuclear hormone corepressor [N-CoR]) have been linked to these functions. Here, we show that the transcriptional corepressor Mtg16 (myeloid translocation gene on chromosome 16), which is targeted by t(16;21) in acute myeloid leukemia, is required for hematopoietic progenitor cell fate decisions and for early progenitor cell proliferation. Inactivation of Mtg16 skewed early myeloid progenitor cells toward the granulocytic/macrophage lineage while reducing the numbers of megakaryocyte-erythroid progenitor cells. In addition, inactivation of Mtg16 impaired the rapid expansion of short-term stem cells, multipotent progenitor cells, and megakaryocyte-erythroid progenitor cells that is required under hematopoietic stress/emergency. This impairment appears to be a failure to proliferate rather than an induction of cell death, as expression of c-Myc, but not Bcl2, complemented the Mtg16(-/-) defect.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 18710942   Authors: Chyla BJ,Moreno-Miralles I,Steapleton MA,Thompson MA,Bhaskara S,Engel M,Hiebert SW
Exact source Fig. 3S: fold change > 1
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(show 2 gene sets from the same authors)
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Organism Mus musculus
Contributed by Arthur Liberzon (MSigDB Team)
Source platform MOUSE_SEQ_ACCESSION
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Version history 3.1: First introduced

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