For the Mouse gene set with the same name, see CLASPER_LYMPHATIC_VESSELS_DURING_METASTASIS_DN

Systematic name M11788
Brief description Selected genes down-regulated during invasion of lymphatic vessels during metastasis.
Full description or abstract Invasion of lymphatic vessels is a key step in the metastasis of primary tumors to draining lymph nodes. Although the process is enhanced by tumor lymphangiogenesis, it is unclear whether this is a consequence of increased lymphatic vessel number, altered lymphatic vessel properties, or both. Here we have addressed the question by comparing the RNA profiles of primary lymphatic endothelial cells (LEC) isolated from the vasculature of normal tissue and from highly metastatic T-241/vascular endothelial growth factor (VEGF)-C fibrosarcomas implanted in C57BL/6 mice. Our findings reveal significant differences in expression of some 792 genes (i.e., >or=2-fold up- or down-regulated, P
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 18794116   Authors: Clasper S,Royston D,Baban D,Cao Y,Ewers S,Butz S,Vestweber D,Jackson DG
Exact source Table 1: fold change < 0
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Source species Mus musculus
Contributed by Jessica Robertson (MSigDB Team)
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Version history 3.0: First introduced

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