Human Gene Set: COLE_BLOOD_FLUZONE_FLUARIX_AGE_03_17YO_7DY_DN


Standard name COLE_BLOOD_FLUZONE_FLUARIX_AGE_03_17YO_7DY_DN
Systematic name M41039
Brief description Genes down-regulated in blood 7d vs 0d in children (3-17) after exposure to Fluzone/Fluarix (IIV) , time point 7D. Comment: IIV (inactivated influenza vaccine)
Full description or abstract BACKGROUND: In recent influenza seasons, the live attenuated influenza vaccine (LAIV) has not demonstrated the same level of vaccine effectiveness as that observed among children who received the inactivated influenza vaccine (IIV). To better understand this difference, this study compared the mRNA sequencing transcription profile (RNA seq) in children who received either IIV or LAIV. METHODS: Children 3-17years of age receiving quadrivalent influenza vaccine were enrolled. Blood samples were collected on Day 0 prior to vaccination and again on Day 7 (range 6-10days) following vaccination. Total RNA was isolated from PAXgene tubes and sequenced for a custom panel of 89 transcripts using the TruSeq Targeted RNA Expression method. Fold differences in normalized RNA seq counts from Day 0 to Day 7 were calculated, log2 transformed and compared between the two vaccine groups. RESULTS: Of 72 children, 46 received IIV and 26 received LAIV. Following IIV vaccination, 7 genes demonstrated significant differential expression at Day 7 (down-regulated). In contrast, following LAIV vaccination, 8 genes demonstrated significant differential expression at Day 7 (5 up-regulated and 3 down-regulated). Only two genes demonstrated similar patterns of regulation in both groups. CONCLUSIONS: Differential regulation of genes was observed between 2015-16 LAIV and IIV recipients. These results help to elucidate the immune response to influenza vaccines and may be related to the difference in vaccine effectiveness observed in recent years between LAIV and IIV.
Collection C7: Immunologic Signature
      VAX: HIPC Vaccine Response
Source publication Pubmed 29132989   Authors: Cole KS,Martin JM,Horne WT,Lin CJ,Nowalk MP,Alcorn JF,Zimmerman RK
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External links https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711596/figure/F1/
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Source species Homo sapiens
Contributed by HIPC SIGNATURES (NIAID/HIPC SIGNATURES)
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