Gene Set: CONRAD_STEM_CELL

Standard name CONRAD_STEM_CELL
Systematic name M15383
Brief description Supplementary Table 2. Genelist comparing microarray expression profiles of spermatogonial cells, haGSCs and hES (H1) cells. Examples of expression rates of different hES cell enriched and germ cell specific genes, surface markers for germ cell selection and signal transduction in all three cell types (spermatogonial cells = SC).
Full description or abstract Human primordial germ cells and mouse neonatal and adult germline stem cells are pluripotent and show similar properties to embryonic stem cells. Here we report the successful establishment of human adult germline stem cells derived from spermatogonial cells of adult human testis. Cellular and molecular characterization of these cells revealed many similarities to human embryonic stem cells, and the germline stem cells produced teratomas after transplantation into immunodeficient mice. The human adult germline stem cells differentiated into various types of somatic cells of all three germ layers when grown under conditions used to induce the differentiation of human embryonic stem cells. We conclude that the generation of human adult germline stem cells from testicular biopsies may provide simple and non-controversial access to individual cell-based therapy without the ethical and immunological problems associated with human embryonic stem cells.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 18849962   Authors: Conrad S,Renninger M,Hennenlotter J,Wiesner T,Just L,Bonin M,Aicher W,Bühring HJ,Mattheus U,Mack A,Wagner HJ,Minger S,Matzkies M,Reppel M,Hescheler J,Sievert KD,Stenzl A,Skutella T
Exact source Table 2S: stem cell enriched genes
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(show 2 gene sets from the same authors)
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Organism Homo sapiens
Contributed by Jessica Robertson (MSigDB Team)
Source platform HUMAN_GENE_SYMBOL
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Version history 3.0: First introduced

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