Systematic name M17557
Brief description Genes down-regulated by MYC [GeneID=4609] and whose promoters are bound by MYC, according to MYC Target Gene Database.
Full description or abstract We report a database of genes responsive to the Myc oncogenic transcription factor. The database Myc Target Gene prioritizes candidate target genes according to experimental evidence and clusters responsive genes into functional groups. We coupled the prioritization of target genes with phylogenetic sequence comparisons to predict c-Myc target binding sites, which are in turn validated by chromatin immunoprecipitation assays. This database is essential for the understanding of the genetic regulatory networks underlying the genesis of cancers.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 14519204   Authors: Zeller KI,Jegga AG,Aronow BJ,O'Donnell KA,Dang CV
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Source species Homo sapiens
Contributed by Chi Dang (Johns Hopkins University)
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Compendia expression profiles ? GTEx compendium
Human tissue compendium (Novartis)
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Version history 3.0: First introduced

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