Gene Set: DAVIES_MULTIPLE_MYELOMA_VS_MGUS_DN

Standard name DAVIES_MULTIPLE_MYELOMA_VS_MGUS_DN
Systematic name M10219
Brief description Genes down-regulated in multiple myeloma (MM) compared to monoclonal gammopathy of uncertain significance (MGUS).
Full description or abstract To define specific pathways important in the multistep transformation process of normal plasma cells (PCs) to monoclonal gammopathy of uncertain significance (MGUS) and multiple myeloma (MM), we have applied microarray analysis to PCs from 5 healthy donors (N), 7 patients with MGUS, and 24 patients with newly diagnosed MM. Unsupervised hierarchical clustering using 125 genes with a large variation across all samples defined 2 groups: N and MGUS/MM. Supervised analysis identified 263 genes differentially expressed between N and MGUS and 380 genes differentially expressed between N and MM, 197 of which were also differentially regulated between N and MGUS. Only 74 genes were differentially expressed between MGUS and MM samples, indicating that the differences between MGUS and MM are smaller than those between N and MM or N and MGUS. Differentially expressed genes included oncogenes/tumor-suppressor genes (LAF4, RB1, and disabled homolog 2), cell-signaling genes (RAS family members, B-cell signaling and NF-kappaB genes), DNA-binding and transcription-factor genes (XBP1, zinc finger proteins, forkhead box, and ring finger proteins), and developmental genes (WNT and SHH pathways). Understanding the molecular pathogenesis of MM by gene expression profiling has demonstrated sequential genetic changes from N to malignant PCs and highlighted important pathways involved in the transformation of MGUS to MM.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 12947006   Authors: Davies FE,Dring AM,Li C,Rawstron AC,Shammas MA,O'Connor SM,Fenton JA,Hideshima T,Chauhan D,Tai IT,Robinson E,Auclair D,Rees K,Gonzalez D,Ashcroft AJ,Dasgupta R,Mitsiades C,Mitsiades N,Chen LB,Wong WH,Munshi NC,Morgan GJ,Anderson KC
Exact source Table 2: Fold change < 0
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Organism Homo sapiens
Contributed by Arthur Liberzon (MSigDB Team)
Source platform HUMAN_SEQ_ACCESSION
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