Human Gene Set: DCA_UP.V1_UP

Standard name DCA_UP.V1_UP
Systematic name M2762
Brief description Genes up-regulated in A549 lung carcinoma and M059K glioblastoma cells treated with dichloroacetate [PubChem=6597].
Full description or abstract Analysis of A549 lung carcinoma and M059K glioblastoma cells treated with dichloroacetate (DCA), an inhibitor of the mitochondrial pyruvate dehydrogenase kinase. DCA shifts metabolism from glycolysis to glucose oxidation and decreases mitochondrial membrane potential in cancer cells.
Collection C6: Oncogenic Signature
Source publication Pubmed 17222789   Authors: Bonnet S,Archer SL,Allalunis-Turner J,Haromy A,Beaulieu C,Thompson R,Lee CT,Lopaschuk GD,Puttagunta L,Bonnet S,Harry G,Hashimoto K,Porter CJ,Andrade MA,Thebaud B,Michelakis ED
Exact source DCA vs Controls; top 200 genes (diff. of means)
Related gene sets (show 1 additional gene sets from the source publication)

(show 13 gene sets from the same authors)
External links
Filtered by similarity ?
Source species Homo sapiens
Contributed by Pablo Tamayo (Broad Institute)
Source platform or
identifier namespace
Dataset references (show 1 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 186 genes
Gene families ? Categorize these 186 genes by gene family
Show members (show 200 source identifiers mapped to 186 genes)
Version history  

See MSigDB license terms here. Please note that certain gene sets have special access terms.