Systematic name M17340
Brief description NF-kB-driven pro-inflammatory genes that are negatively regulated by glucocorticoids.
Full description or abstract A variety of studies have shown that some activated nuclear receptors (NRs), especially the glucorticoid receptor, the estrogen receptor and peroxisome proliferator-activated receptor, can inhibit the activity of the transcription factor nuclear factor kappaB (NF-kappaB), which plays a key role in the control of genes involved in inflammation, cell proliferation and apoptosis. This review describes the molecular mechanisms of cross-talk between NRs and NF-kappaB and the biological relevance of this cross-talk. The importance and mechanistic aspects of selective NR modulation are discussed. Also included are future research prospects, which will lead to a new era in the field of NR research with the aim of specifically inhibiting NF-kappaB-driven gene expression for anti-inflammatory, anti-tumor and immune-modulatory purposes.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 17072333   Authors: De Bosscher K,Vanden Berghe W,Haegeman G
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