Systematic name M7912
Brief description Genes up-regulated in HT-29 cells (colon cancer) by the combination of trichostatin A (TSA) and sodium butyrate [PubChem=5562;5222465].
Full description or abstract A wealth of evidence correlates the chemopreventive activity of a fiber-rich diet with the production of butyrate. In order to identify the genes transcriptionally modulated by the molecule, we analyzed the expression profile of butyrate-treated colon cancer cells by means of cDNA expression arrays. Moreover, the effect of trichostatin A, a specific histone deacetylase inhibitor, was studied. A superimposable group of 23 genes out of 588 investigated is modulated by both butyrate and trichostatin A. Among them, a major target was tob-1, a gene involved in the control of cell cycle. tob-1 is also up-regulated by butyrate in a neuroblastoma-derived cell line, and its overexpression in the colon cells caused growth arrest. Our findings represent an extensive analysis of genes modulated by butyrate and identify completely new effectors of its biological activities.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 11423116   Authors: Della Ragione F,Criniti V,Della Pietra V,Borriello A,Oliva A,Indaco S,Yamamoto T,Zappia V
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Source species Homo sapiens
Contributed by John Newman (University of Washington)
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Version history 3.0: Renamed from BUT_TSA_UP

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