Systematic name M16091
Brief description Genes that escape X inactivation.
Full description or abstract Although the process of X inactivation in mammalian cells silences the majority of genes on the inactivated X chromosome, some genes escape this chromosome-wide silencing. Genes that escape X inactivation present a unique opportunity to study the process of silencing and the mechanisms that protect some genes from being turned off. In this review, we will discuss evolutionary aspects of escape from X inactivation, in relation to the divergence of the sex chromosomes. Molecular characteristics, expression, and epigenetic modifications of genes that escape will be presented, including their developmental regulation and the implications of chromatin domains along the X chromosome in modeling the escape process.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 12900543   Authors: Disteche CM,Filippova GN,Tsuchiya KD
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Source species Homo sapiens
Contributed by Pablo Tamayo (MSigDB Team)
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Version history 3.0: Renamed from DISTECHE_XINACTIVATED_GENES

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