Standard name FARDIN_HYPOXIA_9
Systematic name M2344
Brief description Genes in the hypoxia signature, based on analysis of nine neuroblastoma cell lines in hypoxia and normal oxygen conditions.
Full description or abstract Gene expression signatures are clusters of genes discriminating different statuses of the cells and their definition is critical for understanding the molecular bases of diseases. The identification of a gene signature is complicated by the high dimensional nature of the data and by the genetic heterogeneity of the responding cells. The l1-l2 regularization is an embedded feature selection technique that fulfills all the desirable properties of a variable selection algorithm and has the potential to generate a specific signature even in biologically complex settings. We studied the application of this algorithm to detect the signature characterizing the transcriptional response of neuroblastoma tumor cell lines to hypoxia, a condition of low oxygen tension that occurs in the tumor microenvironment.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 19832978   Authors: Fardin P,Barla A,Mosci S,Rosasco L,Verri A,Varesio L
Exact source Table 2
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Organism Homo sapiens
Contributed by Paolo Fardin (Giannina Gaslini Institute)
Source platform AFFY_HG_U133
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Compendia expression profiles GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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Version history 3.1: First introduced

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