Gene Set: FERRANDO_LYL1_NEIGHBORS

Standard name FERRANDO_LYL1_NEIGHBORS
Systematic name M4175
Brief description Nearest neighbors of LYL1 [GeneID=4066], based on the close agreement of their expression profiles with that of LYL1 in pediatric T cell acute lymphoblastic leukemia (T-ALL).
Full description or abstract Human T cell leukemias can arise from oncogenes activated by specific chromosomal translocations involving the T cell receptor genes. Here we show that five different T cell oncogenes (HOX11, TAL1, LYL1, LMO1, and LMO2) are often aberrantly expressed in the absence of chromosomal abnormalities. Using oligonucleotide microarrays, we identified several gene expression signatures that were indicative of leukemic arrest at specific stages of normal thymocyte development: LYL1+ signature (pro-T), HOX11+ (early cortical thymocyte), and TAL1+ (late cortical thymocyte). Hierarchical clustering analysis of gene expression signatures grouped samples according to their shared oncogenic pathways and identified HOX11L2 activation as a novel event in T cell leukemogenesis. These findings have clinical importance, since HOX11 activation is significantly associated with a favorable prognosis, while expression of TAL1, LYL1, or, surprisingly, HOX11L2 confers a much worse response to treatment. Our results illustrate the power of gene expression profiles to elucidate transformation pathways relevant to human leukemia.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 12086890   Authors: Ferrando AA,Neuberg DS,Staunton J,Loh ML,Huard C,Raimondi SC,Behm FG,Pui CH,Downing JR,Gilliland DG,Lander ES,Golub TR,Look AT
Exact source Fig 2: the LYL+ panel
Related gene sets (show 2 additional gene sets from the source publication)

(show 379 gene sets from the same authors)
External links  
Filtered by similarity
Organism Homo sapiens
Contributed by Jean Junior (MSigDB Team)
Source platform AFFY_HuGene
Dataset references  
Download gene set format: grp | text | gmt | gmx | xml
Compute overlaps (show collections to investigate for overlap with this gene set)
Compendia expression profiles GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 17 genes
Gene families Categorize these 17 genes by gene family
Show members (show 17 members mapped to 17 genes)
Version history 3.0: Renamed from FERRANDO_LYL1_NEIGHBORS

See MSigDB license terms here. Please note that certain gene sets have special access terms.