Standard name |
FULLER_PBMC_F_TULARENSIS_VACCINE_LVS_AGE_22_54YO_18HR_TO_336HR_SUSTAINED_UP |
Systematic name |
M41059 |
Brief description |
Genes up-regulated in peripheral blood mononuclear cell (18 to 336)h vs 0h in adults (22-54) after exposure to F. tularensis vaccine LVS , time point 18 to 336H. Comment: Pattern 3, sustained-up. These approx 9 of 42 genes in pattern linked to immune function. |
Full description or abstract |
The live vaccine strain (LVS) of Francisella tularensis is the only vaccine against tularemia available for humans, yet its mechanism of protection remains unclear. We probed human immunological responses to LVS vaccination with transcriptome analysis using PBMC samples from volunteers at time points pre- and post-vaccination. Gene modulation was highly uniform across all time points, implying commonality of vaccine responses. Principal components analysis revealed three highly distinct principal groupings: pre-vaccination (-144 h), early (+18 and +48 h), and late post-vaccination (+192 and +336 h). The most significant changes in gene expression occurred at early post-vaccination time points (<=48h), specifically in the induction of pro-inflammatory and innate immunity-related genes. Evidence supporting modulation of innate effector function, specifically antigen processing and presentation by dendritic cells, was especially apparent. Our data indicate that the LVS strain of F. tularensis invokes a strong early response upon vaccination. This pattern of gene regulation may provide insightful information regarding both vaccine efficacy and immunopathogenesis that may provide insight into infection with virulent strains of F. tularensis. Additionally, we obtained valuable information that should prove useful in evaluation of vaccine lots as well as efficacy testing of new anti-F. tularensis vaccines. |
Collection |
C7: Immunologic Signature VAX: HIPC Vaccine Response |
Source publication |
Pubmed 17349694 Authors: Fuller CL,Brittingham KC,Porter MW,Hepburn MJ,Petitt PL,Pittman PR,Bavari S |
Exact source |
Table 2 |
Related gene sets |
(show 10 additional gene sets from the source publication)
(show 6 gene sets from the same authors)
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External links |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1986836/table/T2/
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Source species |
Homo sapiens |
Contributed by |
HIPC SIGNATURES (NIAID/HIPC SIGNATURES) |
Source platform or identifier namespace |
HUMAN_GENE_SYMBOL |
Dataset references |
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GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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these 9 genes
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9 genes by gene family
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Show members |
(show 9 source identifiers mapped to 9 genes)
Source Id |
NCBI (Entrez) Gene Id |
Gene Symbol |
Gene Description |
ARRB1 |
408 |
ARRB1 |
arrestin beta 1 [Source:HGNC Symbol;Acc:H... |
ATL3 |
25923 |
ATL3 |
atlastin GTPase 3 [Source:HGNC Symbol;Acc... |
CD300A |
11314 |
CD300A |
CD300a molecule [Source:HGNC Symbol;Acc:H... |
LRP1 |
4035 |
LRP1 |
LDL receptor related protein 1 [Source:HG... |
M6PR |
4074 |
M6PR |
mannose-6-phosphate receptor, cation depe... |
MAPKAPK3 |
7867 |
MAPKAPK3 |
MAPK activated protein kinase 3 [Source:H... |
SPN |
6693 |
SPN |
sialophorin [Source:HGNC Symbol;Acc:HGNC:... |
TXNIP |
10628 |
TXNIP |
thioredoxin interacting protein [Source:H... |
VAMP8 |
8673 |
VAMP8 |
vesicle associated membrane protein 8 [So... |
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Version history |
7.3: First Introduced.
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